Factors Affecting Long-Term Prognosis in Patients with Ischemic Heart Disease Who Underwent Coronary Artery Bypass Grafting

L.M. Yakovleva, Ya.O. Peremot


Objective: to investigate the clinical-anamnestic and genetic factors that influence long-term prognosis in patients with ischemic heart disease (IHD) who underwent coronary artery bypass grafting (CABG).
Materials and Methods. The study involved 79 patients with IHD who underwent CABG. Standard drug therapy was administered to all patients. Follow-up period lasted 3.0 ± 0.2 years. 27 patients who had events that met the study endpoint criteria (cardiovascular death, myocardial infarction, unstable angina, the need for repeat myocardial revasculization (CABG or stenting)), composed I group. 52 patients who had no recorded adverse cardiovascular events were in II group.
Results. It was found, that adverse cardiovascular events in patients with IHD, who underwent CABG, are associated with the presence of arterial hypertension, diabetes mellitus type II, obesity, low physical activity, the extension of atherosclerotic process on peripheral vascular territories, left ventricular ejection fraction less than 35 %, and also with high risk for adverse outcomes of CABG by EuroSCORE scale and low adherence to standard drug therapy. In the presence of D allele and DD genotype of I/D gene polymorphism of the angiotensin-converting enzyme, likelihood of adverse cardiovascular events in patients with ischemic heart disease who underwent CABG, increases by 2.45 and 3.9 times, respectively.


ischemic heart disease; long-term prognosis; risk factors, gene polymorphism


Гены атеросклероза и сердечно-сосудистые заболевания / Н.А. Малыгина, И.В. Костомарова, Н.Н. Водолагина и др. // Клинич. медицина. — 2011. — Т. 89, № 3. — С. 14-18.

Arking D.E. Understanding cardiovascular disease through the lens of genome-wide association studies / D.E. Arking, A. Chakravarti // Trends Genet. — 2009. — Vol. 25. — P. 387-394.

Comparison of the EuroSCORE and Cardiac Anesthesia Risk Evaluation (CARE) score for risk-adjusted mortality analysis in cardiac surgery / D.T. Tran, J.Y. Dupuis, T. Mesana et al. // Eur. J. Cardiothorac. Surg. — 2012. — Vol. 41(2). — P. 307-313. doi: 10.1016/j.ejcts.2011.06.015.

Effect of coronary artery bypass graft surgery on survival: overview of 10 year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration / S. Yusuf, D. Zucker, P. Peduzzi et al. // Lancet. — 1994. — № 344. — Р. 563-570.

Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial / W. Jiang, E.J. Velazquez, M. Kuchibhatla et al. // JAMA. — 2013. — Vol. 309. — P. 2139-2149.

Explaining the decrease in U.S. deaths from coronary disease, 1980–2000 / E.S. Ford, U.A. Ajan, J.B. Croft et al. // N. Engl. J. Med. — 2007. — Vol. 356(23). — P. 2388-2398.

Inducible ischemia and the risk of recurrent cardiovascular events in outpatients with stable coronary heart disease: the heart and soul study / A.K. Gehi, S. Ali, B. Na et al. // Arch. Intern. Med. — 2008. — Vol. 168. — P. 1423-1428.

European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts) / Graham I., Atar D., Borch-Johnsen K. et al. // Eur. J. Cardiovasc. Prev. Rehabil. — 2007. — Vol. 14 (Suppl. 2). — P. S1-113.

International prevalence, recognition and treatment of cardiovascular risk factors in outpatients with atherothrombosis / D.L. Bhatt, P.G. Steg, E.M. Ohman et al. // JAMA. — 2006. — Vol. 295. — P. 180-189.

Katritsis D.G. Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis / D.G. Katritsis, J.P. Ioannidis // Circulation. — 2005. — Vol. 111(22). — P. 2906-2912.

Modifiable risk factors control and its relationship with 1 year outcomes after coronary artery bypass surgery; insights from the REACH registry / R.H. Mehta, D. Bhatt, G. Steg and ASSOCIATE study investigators // European Heart Journal. — 2008. — Vol. 29(24). — P. 3052-3060.

Performance of the original EuroSCORE / S. Siregar, R.H. Groenwold, F. de Heer et al. // Eur. J. Cardiothorac. Surg. — 2012. — Vol. 41(4). — P. 746-754. doi: 10.1093/ejcts/ezr285.

Population-based study of event-rate, incidence, case fata­lity, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study) / P.M. Rothwell, A. Coull, L. Silver et al. // Lancet. — 2005. — Vol. 366. — P. 1773-1783.

Systematic strategy of prophylactic coronary angiography improves long-term outcome after major vascular surgery in medium- to high-risk patients: a prospective, randomized study / M. Monaco, P. Stassano, Di L. Tommaso et al. // J. Am. Coll. Cardiol. — 2009. — Vol. 54. — P. 989–996.

The impact of revascularization on mortality in patients with nonacute coronary artery disease / A. Jeremias, S. Kaul, T.K. Rosengart et al. // Am. J. Med. — 2009. — Vol. 122. — P. 152–161.

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