Experience of Betamethasone Use for the Treatment of Critically Ill Patients

O.O. Pavlov, B.O. Kabakov, M.Ye. Tymchenko

Abstract


In the article the mechanisms of glucocorticoids’ effect in critical conditions, in particular in sepsis, were considered. The objective of the study was to compare the adjunctive treatment with dexamethasone and betamethasone in septic patients after failure of infusion therapy to prevent sympathomimetic resistance. The study showed that the use of corticosteroids in patients with severe septic shock in a mode of low doses leads to a more rapid improvement. When comparing the efficacy of dexamethasone and betamethasone dextrorotatory isomer, there was no difference. Betamethasone is recommended for use in patients with septic shock after failure of infusion therapy and with the development of sympathomimetic resistance.


Keywords


glucocorticoids; sepsis; sympathomimetic resistance; dexamethasone; betamethasone

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DOI: https://doi.org/10.22141/2224-0586.5.52.2013.88903

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