Features of Clinical Course of Ischemic Heart Disease and Prognosis for Patients after Coronary Artery Stenting
Objective — to study the correlation between platelet aggregation parameters in patients after coronary artery stenting, clinical and anamnestic characteristics and drug therapy.
Materials and Methods. Our study included 75 patients with ischemic heart disease: 65 men (86.67 %) and 10 women (13.33 %) with a mean age of 58.0 ± 9.5 years and 59.5 ± 6.0 years, respectively. All patients underwent coronary artery stenting in the period from 2010 to 2012. All patients underwent coronary artery stenting in the period from 2010 to 2012. The complex examination of patients included physical, clinical and instrumental methods of examination (electrocardiography, Holter monitoring, bicycle ergometry, echocardioscopy). Study of platelet aggregation was carried out on a spectrophotometer SF-18 (Leningrad, Russia).
Results and Discussion. The data indicate that 77.3 % of patients were on dual antiplatelet therapy, and 20 % of patients were taking only one antiplatelet drug — acetylsalicylic acid. Patients weren’t significantly different from each other by aggregatogram indices, except «presence of disaggregation» index (100 % vs 80 %, p = 0.019). In patients after coronary artery stenting who had a negative test result in exercise tolerance test, the degree of platelet aggregation was significantly lower than in patients with a positive result of bicycle ergometry.
Conclusions. Dual antiplatelet therapy in patients with ischemic heart disease after coronary artery stenting provides more significant effect on indices of platelet aggregation. Unfavorable course of the disease is associated with inadequate reduction of platelet aggregation level and the lack of disaggregation.
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