Effectiveness of Thiotriazolin in a Complex Treatment of the Patients with Acute Coronary Syndrome without ST Elevation

V.K. Taschuk, N.A. Solobiukova, A.A. Makarov

Abstract


Background. According to ACC/AHA guidelines the short-term goal of the treatment of the patients with unstable angina is a relief of ischemia and prevention of ischemia associated events. Drugs with metabolic action used in a complex therapy along with the basic cardiotropic agents allow enhance the effectiveness of the treatment applied in whole. One of these medications is Thiotriazolin. The aim of the study is to prove more evident effectiveness of the treatment included Thiotriazolin (solution for injections, 25 mg/ml, for a course combined therapy) compared to the standard therapy of acute coronary syndrome (ACS) without ST elevation. Materials and methods. A hundred patients with ACT without ST elevation ended the clinical study (the basic group — 50 people, the control group — 50 people). The main performance indicator was a complex variable included assessment of the following parameters: increased ejection fraction by echo-cardiography over 5 %; reduced overall length of myocardial ischemia episodes within a day by daily ECG Holter monitoring data not less than 10 %; reduced number of ventricular fibrillations by daily ECG Holter monitoring not less than 10 %. Results. The average effectiveness in the basic group was 1.66 points, in the control one — 0.74 points (p < 0.001). The positive effect of the therapy by effectiveness scale was in 84 % and 54 % patients of the basic and control groups, respectively. The following statistically significant changes were revealed: overall length of myocardial ischemia episodes within a day (ECG by Holter) reduced by 26.91 and 11.71 % to the end of the study in the basic and control groups, respectively; daily number of ventricular fibrillations (ECG by Holter) reduced by 34.45 and 30.70 % in the basic and control groups, respectively; end-diastolic volume decreased by 5.44 % in the basic group and increased by 0.5 % in the control group; ejection fraction enhanced by 4.99 % in the basic group and decreased by 0.53 % in the control group; systolic output index increased by 11.40 % and 2.42 % in the basic and control groups, respectively. All adverse reactions and events were predicted and non-serious. Conclusion. Course usage of Thiotriazolin, solution for injection, 25 mg/ml, produced by PC Galychfarm, Ukraine, as an element of a standard therapy of ACS without ST elevation statistically significant raises the effectiveness of the treatment.

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DOI: https://doi.org/10.22141/2224-0586.8.79.2016.90371

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