Impact of Insulin Therapy on Indices of Insulin Resistance and Risk for Cardiovascular Death in Patients with Type 2 Diabetes Mellitus

L.A. Khutorska


The study analyzed the effect of insulin therapy in combination with oral antihyperglycemic drugs (OADs) on glycemic control and risk for coronary heart disease (CHD), as well as the 10-year risk of death from cardiovascular disease in patients with diabetes mellitus (DM) type 2. The study included 66 patients with diabetes mellitus type 2 (39 women and 27 men) aged 39–72 years with duration of diabetes 9.1 ± 1.2 years. CHD risk was calculated in terms of the atherogenic index, and SCORE index. Treatment with long-acting insulin in combination with OADs led to a significant improvement in carbohydrate metabolism, the positive dynamics of lipid metabolism, reduce of microalbuminuria, insulin resistance, and significantly reduced the risk of CHD and a 10-year risk of fatal cardiovascular disease.


type 2 diabetes mellitus; insulin therapy; risk for coronary heart disease and death


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