Evolution of the microbial landscape and current trends of antibiotic resistance formation in pathogenic microrganisms in general intensive care units

M.V. Bondar, M.M. Pylypenko, L.A. Kharchenko, T.V. Ovsienko, O.E. Domoratskiy, M.Yu. Svintukovskyy, S.O. Kondratenko, V.V. Shmorgun


The results of the study of ten-year microbial landscape evolution in the three Kyiv general intensive care units (ICUs) and modern trends in the formation of antibiotic resistance in the leading microbial pathogens have been shown in this article. The main outcome of the ten-year evolution of microbial landscapes of ICUs is the disappearance from a pathogenic microbial spectrum of methicillin-resistant Staphylococcus aureus, move of Pseudomonas aeruginosa from the first to fourth-fifth place in the structure of causative agents of infection processes in patients of ICUs and taking a leading positions by Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus faecalis. This article has shown the results of antibiotic resistance of the leading microbial pathogens to the entire spectrum of antibacterial drugs and specific recommendations for the rational empirical antibiotic therapy.


general intensive care units; microbial landscape; pathogenic microflora; antibiotic resistance; rational antibiotic therapy


Бондар М.В., Пилипенко М.М., Свінтуковський М.Ю., Харченко Л.А., Перевисла О.М., Цвик І.М. Антибіотикорезистентність мікроорганізмів: механізми розвитку й шляхи запобігання // Медицина невідкладних станів. — 2016. — № 3(74). — С. 11-15.

Воробьев А.А. Медицинская микробиология, вирусология и иммунология: Учебник / А.А. Воробьев, А.С. Быков, М.Н. Бойченко [и др.]; под ред. А.А. Воробьева. — 2-е изд., исправ. и доп. — М.: МИА, 2012. — 702 с.

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