The correlation indices in patients with multiorgan dysfunction syndrome

I.R. Malysh, L.V. Zgrzheblovskaya

Abstract


The article is devoted to the investigation of correlation levels between colloids and crystalloids and different physiologic variables on the 12th day after injury. The study suggested that cumulative dose of colloids tightly interrelated with extravascular fluid volume and balance, parameters of ventilation and gas exchange. It was likely associated with colloid mo­lecules penetration against capillary flow syndrome promoting increased interstitial hydration, impaired respiratory metabolism. The examination of renal functioning found out negative interrelation between colloids cumulative dose and filtration gradient, glomerular filtration rate and positive interrelations with blood serum creatinine levels. Perhaps, englobing of colloid molecules in interstitial space by the cells of monocyte-macrophage system results in severe impairment of phagocytosis along with the further antigen presentation. The investigation of immune response has shown that there is negative correlation between cumulative doses of colloids and activity of innate immunity, except for sodium and chloride blood levels.

Keywords


multiple injury; multiorgan dysfunction syndro­me; colloids; crystalloids; correlation

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DOI: https://doi.org/10.22141/2224-0586.1.80.2017.94461

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