The modified infusion therapy and adrenomimetic support and indicators of functional gut condition in multiple organ dysfunction syndrome in victims with severe concomitant injury

I.R. Malysh, L.V. Zgrzheblovskaya


The article deals with the investigation of influence of the modified infusion therapy and adrenomimetic support on the gut function. It was established that applied protocol of modified infusion therapy according to the stage of postinjury period provided stable levels of inraabdominal and abdominal perfusion pressure during all observation period. It was also found that the levels of abdominal perfusion pressure in group with protocol of modified infusion therapy according to the stage of postinjury period were 8.41–19.35 %; tolerated volume of enteral nutrition — 26.92–41.50 % higher; the level of inraabdominal pressure — 22.39–22.46 % lower in comparison to the control group. The application of protocol of modified infusion therapy and adrenomimetic support according to the stage of postinjury period was accompanied by increase of abdominal perfusion pressure, volumes of tolerated enteral nutrition. This can be explained by the influence of noradrenaline infusion on splanchnic circulation.


severe injury; multiple organ dysfunction syndrome; infusion therapy; adrenomimetic correction; gut


O’Mara M.S., Slater H., Goldfarb I.W., Caushaj P.F. A prospective, randomized evaluation of intra-abdominal pressures with crystalloid and colloid resuscitation in burn patients // J. Trauma. — 2011. — Vol. 58. — P. 1011-1018.

Ziakas P.D., Voulgarelis M., Felekouras E., Anagnostou D., Tzelepis G.E. Myelofibrosis-associated massive splenomegaly: a cause of increased intra-abdominal pressure, pulmonary hypertension, and positional dyspnea // Am. J. Hematol. — 2013. — Vol. 80. — P. 128-132.

Hamad G.G., Peitzman A.B. Morbid obesity and chronic intra-abdominal hypertension / Ivatury R., Cheatham M., Malbrain M., Sugrue M. // Abdominal Compartment Syndrome. — Landes Bioscience, Georgetown, 2014. — Р. 187-194.

Sugerman H.J. Effects of increased intra-abdominal pressure in severe obesity // Surg. Clin. North Am. — 2011. — Vol. 81. — P. 1063-1075.

Sugerman H.J. Increased intra-abdominal pressure in obesity // Int. J. Obes. Relat. Metab. Disord. — 2008. — Vol. 22. — P. 1138-1140.

Sugerman H.J., DeMaria E.J., Feiton W.L. III, Nakatsuka M., Sismanis A. Increased intraabdominal pressure and cardiac filling pressures in obesity — associated pseudotumor cerebri // Neurology. — 2014. — Vol. 49. — P. 507-511.

Kimball E.J., Kinikini D.V., Mone M.C. Delayed abdominal closure in the management of ruptured abdominal aortic aneurysm // Crit. Care Med. — 2016. — Vol. 33 (Suppl. 12). — P. 38-40.

Kimball E.J. Intra-abdominal hypertension and the abdominal compartment syn­drome: ARDS’ of the gut // Int. J. Intensive Care. — 2016. — Vol. 4. — P. l-7.

Kirkpatrick A.W., Balogh Z., Ball C.G. The secondary abdominal compartment syndrome: iatrogenic or unavoidable? // J. Am. Coll. Surg. — 2013. — Vol. 202. — P. 668-679.

Reintam A., Parm P., Kitus R., Starkopf J., Kern H. Gastrointestinal Failure Score in critically ill patients: a prospective observational study // Crit. Care. — 2012. — Vol. 12. — P. 90-95.

Michard M., Teboul J.L. Predicting of fluid responsiveness in ICU patients: a critical analysis of evidence // Chest. — 2012. — Vol. 121. — Р. 2000-2008.

Malbrain M.L. Different techniques to measure intra-abdominal pressure (IAP): time for a critical re-appraisal // Intensive Care Med. — 2014. — Vol. 30. — P. 357-371.

Copyright (c) 2017 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта