Sodium lactate — choice for infusion solutions with alkaline reserve

A.S. Sokolov, A.V. Korshunov, V.S. Rustamova, A.L. Chernov


Despite of the age-old term from the moment of usage, multicomponent infusion solutions based on sodium lactate as a carrier of alkaline reserve remain the basis of rational balanced infusion therapy for both critical patients and patients with a general-somatic profile. The uniqueness of the composition, which is close to “ideal solution”, provides wide indications for use. Ringer lactate continues to be one of the most popular infusion solutions in the world, as reflected in a number of guidelines. The appearance in the clinical practice of domestic polyionic multifunctional solutions — Rheosorbilact and others has given an impulse to the development of new methods of therapies. Rheosorbilact in clinical practice has established itself as an effective mean for correcting volemic, rheological disorders, eliminating shifts in the acid-bas balance, treatment of intoxication syndrome.


sodium lactate; infusion therapy


Strunden M.S., Heckel K., Goetz A.E., Reuter D.A. Perioperative fluid and volume management: physiological basis, tools and strategies // Ann. Intensive Care. — 2011. — 1, 2. — Published online. — 2011, Mar 21. — doi: 10.1186/2110-5820-1-2.

Myburgh J.A., Mythen M.G. Resuscitation fluids // N. Engl. J. Med. — 2013. — V. 369. — P. 1243-1251.

Инфузионная терапия при критических состояниях / А.С. Владыка, В.В. Суслов, О.А. Тарабрин; под ред. проф. В.В. Суслова. — К.: Логос, 2010. — 274 с.

Moore F.D. Metabolic care of the surgical patient / Ed. by W.B. Saunders. — Philadelphia, 1961.

Stewart P.A. Modern quantitative acid-base chemistry // Can. J. Physiol. Pharmacol. 1983; 61: 1444-1461.

Stewart P.A. Independent and dependent variables of acid-base control // Respir. Physiol. 1978; 33: 19-26.

Morgan T.J. Acid-base and bio-energetics during balanced versus unbalanced normovolaemic haemodilution / T.J. Morgan, B. Venkatesh, A. Beindorf et al. // Anaesth. Intensive Care. 2007; 35: 173-179.

Yunos N., Bellomo R., Hegarty C., Story D., Ho L., Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults // JAMA: The Journal of the American Medical Association. 2012; 308 (15): 1566-1572. (Guideline Ref ID YUNOS2012)

Story D.A., Morimatsu H. and Bellomo R. Strong ions, weak acids and base excess: a simplified Fencl-Stewart approach to clinical acid-base disorders // British Journal of Anaesthesia. 2004; 92, 1: 54-60.

Story D.A., Liskaser F., Bellomo, R. Saline infusion, acidosis, and the Stewart approach // Anesthesiology. 2000; 92 (issue 2): 624.

Williams E.L., Hildebrand K.L., McCormick S.A. et al. The Effect of intravenous lactated Ringer's solution versus 0.9 % sodium chloride solution on serum osmolality in human volunteers // Anesth. Analg. 1999; 88: 999-1003.

Takil A., Eti Z., Irmak P., Gögüs F. Early postoperative respiratory acidosis after large intravascular volume infusion of lactated Ringer's solution during major spine surgery // Anesth. Analg. 2002; 95: 294-298.

Scheingraber S., Rehm M., Sehmisch C., Finsterer U. Rapid saline infusion produces hyperchloraemic acidosis in patients undergoing gynecologic surgery // Anesthesiology. 1999; 90 (5): 1265-1270.

Mirza B.I., Sahani M., Leehey D.J. et al. Saline_induced dilutional acidosis in a maintenance hemodialysis patient // Int. J. Artif. Organs. 1999; 22: 676-678.

Jaber B.L., Madias N.E. Marked dilutional acidosis complicating management of right ventricular myocardial infarction // Am. J. Kidney Dis. 1997; 30: 561-567.

Lang W., Zander R. The accuracy of calculated base excess in blood // Clin. Chem. Lab. Med. 2002; 40: 404-410.

Герасимов Л.В., Мороз В.В. Водно-электролитный и кислотно-основный баланс у больных в критических состояниях // Общая реаниматология. — 2008. — 4, 4. — C. 79-85.

Morgan T.J., Venkatesh B., Hall J. Crystalloid strong ion difference determines metabolic acid_base change during in vitro hemodilution // Crit. Care Med. 2002; 30: 157-160.

Gernot Marx, Achim W. Schindler, Christoph Mosches. Intravascular volume therapy in adults (Guidelines from the Association of the Scientific Medical Societies in Germany) // Eur. J. Anaesthesiol. 2016; 33: 1-34.

Intravenous fluid therapy in adults in hospital. NICE clinical guideline 174 (December 2013. Last update October 2016,

Intravenous fluid therapy in children and young people in hospital (2015) NICE guideline NG29 Sepsis: recognition, diagnosis and early management NICE guideline [NG51] Published date: July 2016 Last updated: July 2016

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock // Intensive Care Med. 2013; 39(2): 165-228.

Wilcox C.S. Regulation of renal blood flow by plasma chloride // J. Clin. Invest. 1983; 71: 726-735.

Kellum J.A., Song M., Venkataraman R. Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules inexperimental sepsis // Chest. 2004; 125 (1): 243-248.

Morgan T.J. The meaning of acid_base abnormalities in the intensive care unit: part III — effects of fluid administration // Crit. Care. 2005; 9(2): 204-211.

Wilkes N.J., Woolf R., Mutch M. et al. The effects of ba­lanced versus saline based hetastarch and crystalloid solutions on acid base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth. Analg. 2001; 93: 811-816.

Wilkes N.J., Woolf R., Mutch M. et al. The effects of ba­lanced versus saline_based hetastarch and crystalloid solutions on acid_base and electrolyte status and gastric mucosal perfusion in elderly surgical patients // Anesth. Analg. 2001; 93: 811-816.

Catherine M.N., O'Malley H., Robert J. et al. A randomi­zed, doubleb-lind comparison of lactated Ringer's solution and 0.9 % NaCl during renal transplantation // Anesth. Analg. 2005; 100: 1518-1524.

Prowle J.R. Fluid administration and the kidney / J.R. Prowle, R. Bellomo // Curr. Opin. Crit. Care. 2013 Aug; 19 (4): 308-14.

Smith C.A. Cost-minimization analysis of two fluid products for resuscitation of critically injured trauma patients / C.A. Smith, J.J. Duby, G.H. Utter et al. // Am. J. Health Syst. Pharm. 2014; 71: 470-475.

Waters J.H., Gottlieb A., Schoenwald P. et al. Normal saline versus lactated Ringer's solution for intraoperative fluid ma­nagement in patientsundergoing abdominal aortic aneurysm repair: an outcome study // Anesth. Analg. 2002; 95 (1): 256.

Martin G., Wakeling H., El-Moalem H. et al. A prospective, randomizedcomparison of thromboelastographic coagulation profile in patientsreceiving lactated Ringer's solution, 6 hetastarch in a balanced salinevehicle, or 6 % hetastarch in saline during major surgery // J. Cardiothorac. Vasc. Anesth. 2002; 16: 441-446.

Kellum J.A. Hyperchloremic acidosis increases circulationg inflammatory molecules in experimental sepsis / J.A. Kellum, M. Song, E. Almasri // Chest. 2006; 130: 962-967.


Valeri C.R. Effects of the resuscitation fluid and the hemoglobin based oxygen carrier (HBOC) excipient on the toxicity of the HBOC: Ringer’s D,L-lactate, Ringer’s L-lactate, and Rin­ger’s ketone solutions / C.R. Valeri, G. Ragno, R.L. Veech // Artif. Cells Blood Substit. Immobil. Biotechnol. 2006; 34: 601-606.

Gunnerson K.J. Lactate versus nonlactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients / K.J. Gunnerson, M. Saul, S. He, J.A. Kellum // Crit. Care. 2006; 10: R22.

Morgan J. The meaning of acid-base abnormalities in the intensive care unit: Part III — effects of fluid administration // Critical Care. 2005; 9: 204-211.

British Consensus Guidelines on Intravenous Fluid The­rapy for Adult Surgical Patients (4 июня 2012).

Captain Thileepan Naren, Colonel Alistair Royse and Lieutenant Colonel Michael C. Reade Review of fluid resuscitation and massive transfusion protocols from a military perspective ADF // Health. 2011; 12, 1.

Schreiber M.A. The use of normal saline for resuscitation in trauma // Journal of Trauma-Injury Infection and Critical Care. 2011; 70 (5): S13-S14.

Горовенко Н.Г., Гуменюк Н.И., Деркач Н.Н. Использование инфузионных растворов для коррекции метаболического ацидоза // Український хіміотерапевтичний журнал. — 2008. — № 1–2 (22). — С. 29-32.

Глумчер Ф.С., Стрепетова О.В., Перебийнис М.В. Применение реосорбилакта в комплексной терапии больных с алкогольной интоксикацией // Український хіміотерапевтичний журнал. — 2012. — № 3 (26). — С. 50-53.

Захараш М.П., Кучер Н.Д., Пойда А.И., Яремчик И.А. Роль препарата Сорбилакт в раннем послеоперационном периоде у больных колопроктологического профиля // Мистецтво лікування. — 2004. — № 9. — С. 28-29.

Волков А.В., Постернак Г.И., Ткачева М.Ю. Опыт применения препаратов сорбилакт и реосорбилакт в комплексной терапии больных с синдромом диабетической стопы // Український хіміотерапевтичний журнал. — 2008. — № 1–2 (22). — С. 99-100.

Гуменюк Н.И., Морская Н.Д., Яхница Т.В., Ломтева Е.А., Беренда Е.А. Влияние реосорбилакта на газовый состав и кислотно-основное состояние крови у больных с хроническим легочным сердцем и гиперкапнией // Український пульмонологічний журнал. — 2005. — № 4. — С. 34-37.

Хамидов Д.Б., Косимов З.К., Хомидов Д.Д., Киямов С.Э. Комплексный полифункциональный раствор реосорбилакт в интенсивной терапии эндогенной интоксикации у больных с острым перитонитом // Научно-практический журнал ТИППМК. — 2011. — № 2. — С. 77-79.

Рижко О.О. Інфузійна терапія реосорбілактом // Укр. пульмонол. журнал. — 2003. — № 2. — С. 334-335.

Чепкий Л.П., Главацкий А.Я., Гавриш Р.В. и др. Интенсивная терапия отека головного мозга при хирургическом лечении опухолей мозга // Біль, знеболювання і інтенсивна терапія. — 2002. — № 2. — С. 23-28.

Гуменюк Н.И., Ломтева Е.А. Влияние инфузионных препаратов на основе сорбитола и натрия лактата на агрегацию тромбоцитов in vitro у больных с хроническим легочным сердцем // Укр. пульмонол. журн. — 2005. — № 2. — С. 54-56.

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