Analgin — Effectively? Cheap? Safely? What is the Alternative?

A.S. Sokolov, V.V. Nikonov, A.E. Feskov


The problem of the treatment of post-operative pain and the pain itself remains an open problem of modern medicine. Current World Health Organization (WHO) recommendations and guidelines on the management of postoperative pain clearly indicate the need for using highly effective and safe nonopiate analgesics. The modern medical world is moving away from the use of metamizole (analgin) in the practice of acute pain relief. The current concept of effective control of postoperative pain — a multimodal approach with the use of modern, effective, safe drugs, particularly intravenous form of acetaminophen (paracetamol). Acetaminophen is approved by Food and Drug Administration for use in the USA over 50 years. Today, the drug is available in many countries without a prescription. Ace­taminophen has proven its effectiveness in many clinical trials, and is included in numerous recommendations for the treatment of chronic and postoperative pain syndrome (POPS) (WHO, 2013; Ministry of Health of Ukraine, 2014; Guidelines on the Management of Postoperative Pain, 2016). The appearance of the intravenous form of acetami­nophen on the market of pharmaceutical products expanded his using and has made it possible to reconsider approaches to control POPS, to fully apply the principle of multimodal postoperative ­analgesia.


metamizole; acetaminophen; pain; postoperative analgesia


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