Drug-induced liver damage: principles of diagnosis, pathological changes and treatment approaches

Authors

  • S.M. Nedashkivskyi Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0586.2.97.2019.161644

Keywords:

hepatotoxicity, mechanisms of toxic reaction to drugs, paracetamol, hepatocellular insufficiency, cholestasis, liver cirrhosis, hepatic encephalopathy

Abstract

The paper presents data on the frequency of drug-induced liver injury. Pathophysiological mechanisms of changes occurring under the influence of hepatotoxic drugs are considered. Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure. Knowledge of the commonly implicated agents and a high index of suspicion are essential in diagnosis.

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References

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Published

2019-04-30

How to Cite

Nedashkivskyi, S. (2019). Drug-induced liver damage: principles of diagnosis, pathological changes and treatment approaches. EMERGENCY MEDICINE, (2.97), 63–70. https://doi.org/10.22141/2224-0586.2.97.2019.161644

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Section

Original Researches

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