Intraoperative use of urapidil in emergency gynecology
Keywords:urapidil, intraoperative period, hypertension
Background. During anesthetic management, it is not always possible to avoid an intraoperative increase in blood pressure, which requires medical correction. α-adrenoreceptor blockers are effective in terms of normalizing blood pressure in operative hypertension. The purpose of our study was to evaluate the efficacy and tolerability of urapidil in the intraoperative therapy of patients with hypertension in emergency gynecology. Materials and methods. The first group (n = 20) included patients with no history of elevated blood pressure (the first registration of high blood pressure was on the operating table); the second group (n = 20) — females who regularly took antihypertensive drugs. Urapidil was prescribed according to the following scheme: first, the drug was injected with an intravenous bolus dose of 25 mg and then, to maintain a stable blood pressure level, urapidil at a dose of 100 mg was added to 30 ml of 0.9% sodium chloride solution and injected with the help of infusion pump at a rate of 8.1 ± 0.9 mg/h in the first group of patients and 7.8 ± 1.0 mg/h in the second group. Conclusions. The use of urapidil in the treatment of perioperative hypertension makes it possible to effectively control blood pressure both in patients who have not been diagnosed with hypertension previously, and in patients who have taken first-line antihypertensive drugs regularly.
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