Zinc concentration in cerebral and intestinal tissues in case of acute cerebral insufficiency

Authors

  • P.S. Teriv Ukrainian Medical Stomatological Academy, Poltava, Ukraine

DOI:

https://doi.org/10.22141/2224-0586.5.100.2019.177022

Keywords:

acute cerebral insufficiency, intestine, zinc

Abstract

Background. In acute cerebral insufficiency, other organs become targets of extracerebral lesions. One of the links in the formation of cerebrovisceral lesions, in particular with the participation of the gastrointestinal tract, may be impaired zinc metabolism. The purpose of the study is to determine the role of zinc content disorder in the formation of cerebral and gastrointestinal disorders in critically ill patients. Materials and methods. Through atomic absorption spectrophotometry, zinc level was studied using autopsy specimen of 21 persons with acute cerebral insufficiency: in 71 % of cases (15/21), cerebral circulation by hemorrhagic type was a major pathology, in 29 % (6/21) — by ischemic type. Tissues of intact hippocampus, zone of cerebral lesion, small intestine were investigated. Results. It was found that patients with acute cerebral insufficiency had a low zinc level in all studied tissues: in the specimen of the intact hippocampus — in 95 % of cases (U = 420. p < 0.001), of the cerebral lesion zone — in 81 % (U = 357, p < 0.001), of the small intestine — in 100 % (U = 441, p < 0.001). The changes in zinc content did not show a significant difference depending on the nature of the underlying disease. Significant correlations were found between zinc content in the small intestine and cerebral lesion zone (R = 0.58; p = 0.005), in the intact hippocampus and cerebral lesion zone (R = 0.58; p = 0.005). The survival rate was not related to the zinc level in the brain tissues, but its content in the intestinal tissues directly correlated with survival on day 3 (R = 0.5; p = 0.02). Conclusions. Thus, in patients with acute cerebral insufficiency in the area of cerebral lesion, intact hippocampus and the wall of the small intestine, a low zinc contents were detected, which are interrelated and do not depend on the nosological form of the disease. The survival of patients with acute cerebral insufficiency has a direct correlation with zinc content in the small intestine on day 3 of the disease, indicating the need for its correction within 3 days of treatment.

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Published

2021-10-01

How to Cite

Teriv, P. (2021). Zinc concentration in cerebral and intestinal tissues in case of acute cerebral insufficiency. EMERGENCY MEDICINE, (5.100), 74–78. https://doi.org/10.22141/2224-0586.5.100.2019.177022

Issue

Section

Original Researches