Dynamics of markers of the autoimmune response of the body to markers of nervous system disorder as a reaction of patients to surgical intervention with the use of artificial blood circulation

Authors

  • K.A. Khizhnyak Kharkiv National Medical University, Kharkiv, Ukraine State Institution “Amosov National Institute of Cardiovascular Surgery of the NAMS of Ukraine”, Kyiv, Ukraine
  • Yu.V. Volkova Kharkiv National Medical University, Kharkiv, Ukraine http://orcid.org/0000-0002-6248-3576
  • K.Yu. Sharlai Kharkiv National Medical University, Kharkiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0586.5.100.2019.177018

Keywords:

markers of autoimmune response, markers of damage to the nervous system, extracorporeal circulation

Abstract

Background. The problem of central nervous system disorders in the structure of cardiac surgical complications remains relevant. Therefore, the purpose of this study is to analyze the dynamics of markers of the autoimmune response of the body to markers of nervous system disorders as a reaction of patients to surgical intervention performed using cardiopulmonary bypass (CPB). Materials and methods. The basis of this study is the analysis of the results of a survey of 118 patients with surgical aortic pathology. The patients were divided into 2 groups according to the principle of using additional substances as a part of intensive care (IC). Group I consisted of 46 patients who, in addition to the IC algorithm, received meglumine sodium succinate solution (reamberin). Group II included 46 persons who, in addition to the IC algorithm, received a solution of D-fructose-1,6-diphosphate sodium salt hydrate (esafosfina). The control group consisted of 26 patients who had surgical aortic pathology and the same criteria as patients of groups I and II, but they did not received additional supplements in IC for the purpose of preventing postoperative cognitive dysfunction. To study the autoimmune response, serum levels of autoantibodies to brain antigens (myelin basic protein (MBP), S-100 calcium binding protein, neuron-specific enolase (NSE) and total human brain antigen (THBA)) were determined by enzyme-linked immunosorbent assay the day before surgery, on days 1, 3, 7 and 14 after surgery. Results. It was found that the fact of anesthesia support with the use of CPB itself negatively affects the state of the brain as a whole. This is proved by the dynamics of A-MBP, A-S-100, A-NSE and A-THBA indicators in patients of control group, that is, without additional administration of substances as a part of current protocol in order to control CPB consequences. Changes in the studied autoantibodies, which are responsible for the various histological and functional structures of the brain, can be explained by the general reaction of the body to the physical conditions of CPB. But determination of the component of artificial perfusion, which most influences the functional state of patient’s brain, does not depend on their initial state, but makes a difference from the baseline level of immune parameters and requires further research. Conclusions. Thus, it can be noted that the administration of a solution of D-fructose-1,6-diphosphate sodium salt hydrate (esafosfina) has the most positive effect on the functional state of the cells responsible for the cognitive functions in patients with surgical aortic pathology.

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Published

2021-10-01

How to Cite

Khizhnyak, K., Volkova, Y., & Sharlai, K. (2021). Dynamics of markers of the autoimmune response of the body to markers of nervous system disorder as a reaction of patients to surgical intervention with the use of artificial blood circulation. EMERGENCY MEDICINE, (5.100), 50–57. https://doi.org/10.22141/2224-0586.5.100.2019.177018

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Original Researches

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