Leading pathophysiological disorders in acute bowel obstruction (a clinical lecture)

Authors

  • M.M. Pylypenko Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • M.V. Bondar Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0586.16.2.2020.203140

Keywords:

acute bowel obstruction, loss of fluid and electrolytes, hyponatremia, hypokalemia, hypocalcemia, gut flora translocation, pressure in the intestinal lumen, intra-abdominal pressure, dynamic bowel obstruction

Abstract

The article outlines modern views on the pathogenesis of acute bowel obstruction and summarizes the leading local and systemic pathophysiological disorders. It was emphasized both the common aspects, as well as differences in the pathogenesis of “high” and “low” acute bowel obstruction and the particular attention was paid to the specifics of the leading electrolyte disorders in each of the types. The main stages of the pathogenesis of local disorders and systemic effects are described and in particular, the article focuses on dysbiosis and gut microflora translocation, elevated pressure in the intestinal lumen and intraabdominal hypertension. The role of pain in the progression of respiratory disorders and cardiovascular activity is described. Special attention is paid to the pathogenesis of postoperative dynamic small bowel obstruction. Each section emphasizes the clinically significant disorders, the knowledge of which may be the key to the correct choice of intensive therapy methods, and finally the improvement of treatment results.

Downloads

Download data is not yet available.

References

Бондарь М.В. Физиология и патология водно-электролитного обмена. В кн.: Руководство по интенсивной терапии. Под ред. проф. А.И. Трещинского, Ф.С. Глумчера. К.: Вища школа, 2004. 251-311.

Wauters J., Claus P., Brosens N. et al. Relationship between Abdominal Pressure, Pulmonary Compliance, and Cardiac Preload in a Porcine Model. Crit. Care Res. Pract. 2012. 2012. 763181.

Malbrain M.L., Peeters Y., Wise R. The neglected role of abdominal compliance in organ-organ interactions. Crit. Care. 2016 Mar 16. 20. 67.

Van Damme L., De Waele J.J. Effect of decompressive laparotomy on organ function in patients with abdominal compartment syndrome: a systematic review and meta-analysis. Crit. Care. 2018 Jul 25. 22(1). 179.

Luchey A., Livingston E., Tache Y. Mechanism and treatment of postoperative ileus. Arch. Sugr, 2003. 138. 206-214.

Boeckxstaens G.E., de Jonge W. J. Neuroimmune mechanisms in postoperative ileus. Gut. 2009. 58. 1300-1311

Kurz A., Sessler D.I. Opioid-induced bowel dysfunction: pathophysiology and potential new therapies. Drugs. 2003. 63. 649-671.

Published

2021-09-30

How to Cite

Pylypenko, M., & Bondar, M. (2021). Leading pathophysiological disorders in acute bowel obstruction (a clinical lecture). EMERGENCY MEDICINE, 16(2), 42–48. https://doi.org/10.22141/2224-0586.16.2.2020.203140

Issue

Section

Lecture

Most read articles by the same author(s)

1 2 3 4 > >>