Rational antibiotic therapy of basic microbial pathogens in intensive care units


  • M.V. Bondar Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • M.M. Pylypenko Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • I.A. Kuchynska Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine




basic microbial pathogens in intensive care units, antibiotic resistance, rational antibiotic therapy, reserve antibiotics, colomycin, fosfomycin, gentamicin, tobramycin, amikacin, protected penicillins, protected cephalosporins, glycopeptides


The article presents the results of a 10-year study of the evolution of the microbial landscape in the intensive care units (IT) of a general profile in Kyiv. It has been established that the main reason for the selection of pathogenic microflora in IT departments is the formation of antibiotic resistance to the basic microbial pathogens as a result of the widespread use of antibiotic therapy. Today, the leading microbial pathogens in the general IT departments are Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus faecalis, Enterococcus faecium, and Pseudomonas aeruginosa. The morphological features of these microorganisms and the mechanisms of their pathogenic action on the human body are described. The results of our own studies of the sensitivity of these microorganisms to antibiotics with the definition of optimal antibiotic therapy programs are presented. Based on the analysis of the world literature, the question of the advisability of using antimicrobial therapy against the basic microbial pathogens in the IT departments using the antibiotics most effective to the above microbial pathogens was considered.


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How to Cite

Bondar, M., Pylypenko, M., & Kuchynska, I. (2021). Rational antibiotic therapy of basic microbial pathogens in intensive care units. EMERGENCY MEDICINE, 16(3), 15–21. https://doi.org/10.22141/2224-0586.16.3.2020.203160



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