Acute ethylene glycol poisoning in clinical practice

Authors

  • S.M. Stadnik Military Medical Clinical Center of the Western Region, Lviv, Ukraine
  • B.S. Porodko Military Medical Clinical Center of the Western Region, Lviv, Ukraine

DOI:

https://doi.org/10.22141/2224-0586.16.4.2020.207942

Keywords:

acute poisoning, surrogate alcohol, ethylene glycol, hemodialysis

Abstract

Poisoning is an ongoing problem in clinical medicine. Its frequency increases in proportion to the urbanization of the population and the increase in the consumption of chemicals in the household. In the total number of acute and chronic poisoning, household poisoning prevails, accounting for 90 %. The lion’s share among them is alcohol poisoning and its substitutes. Ethylene glycol poisoning occupies a special place among acute poisoning with alcohol substitutes. According to the statistics, ethylene glycol poisoning occupies the second among intoxications with technical fluids. The availability of ethylene glycol and lack of public awareness about its poisonous properties is a condition for the occurrence of poisoning. The clinical picture of ethylene glycol intoxication is characterized by the development of three successive stages: the first stage — CNS depression (narcotic phase), the second stage — toxic lesions of the heart and the lungs, the third stage — toxic lesions of the liver and kidneys. The article presents a case report of acute ethylene glycol poisoning, gives the results of the diagnostic activities, the dynamics of the clinical manifestations and laboratory parameters, describes the treatment of a patient. The role of hemodialysis therapy in cases of ethylene glycol poisoning is shown

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References

Akhmetov I.R. Hospitalization in the toxicology department and intensive care. Comparative analysis // Materials Rus. scientific conf. «Medical aspects of radiation and chemical safety». – SPb., 2001. – P. 363–364.

Akhmetov K.Zh., Turdalina А.К., Kulmyrzayeva Н.К. Poisoning with alcohol and its substitutes // Medical journal of west Kazakhstan. – 2010. – № 1 (25). – P. 100–102.

Berezhnoy R.V. Forensic-medical examination of poisoning by technical fluids. – М.: The medicine, 1977. – 208 p.

Bonitenko E.Yu. Comparative characteristics of poisoning by ethylene glycol and its esters // Russian Biomedical Journal. – 2003. – Vol. 4. – P. 486–490.

Report on prevention of child injury in Europe. Copenhagen, Regional Office for Europe of WHO, 2009. – 98 p.

Kravchenko A.M., Malayeva1 E.G., Hudyakov I.A. A clinical case of acute ethylene glycol poisoning // Problems of health and ecology. – 2016. – № 2 (48). – P. 90–95.

Kurazov B.R. Hemodialysis therapy for poisoning of ethylene glycol. Clinical case // Vestnik of KazNMU. – №2 – 2013. – 232 p.

Kurlandsky B.A., Filov V.A. General toxicology. − М.: The medicine, 2002. – 608 p.

Luzhnikov E.A. Clinical Toxicology. – М. : The medicine, 1999. – 416 p.

Luzhnikov E.A., Kostomarova L.G. Acute poisoning: a guide for doctors. – М.: The medicine, 2000. – 434 p.

Luzhnikov E.A. Emergency clinical toxicology (a guide for doctors). − М.: Medical practice, 2007. – 608 p.

Markova I.V., Afanasyev V.V., Tsibulkin E.K. Clinical toxicology of children and adolescents. − SPb.: «Intermedica», 1998. – Vol. 1. – 304 p.

Mashanov A.V., Yushkov G.G. To the question of antidote treatment of acute poisoning with alcohol, its surrogates and carbon monoxide: an analytical review // Vestnik AGTA. – № 1, Vol. 2. – 2008. – P. 89–92.

Nikonov V.V., Kursov S.V., Iyevleva V.I. Peculiarities of clinical picture of acute poisonings with some alcohol surrogates: cardiac depressant effect // Emergency medicine. – 2014. – № 6 (61) – P. 175–179.

Nurgaliev E.V., Imamov A.A. Poisoning with alcohol and its surrogates // Abstracts of the 2nd congress of toxicologists of Russia 10–13 Nov., 2003. – М., 2003. – P. 389–390.

Ovseyuk U.A., Zhukova A.A., Zinovkin D.A. Pathological and morphological changes in the internal organs of human and white rat at ethylene glycole poisoning // Problems of health and ecology. – 2010. – № 1 (23). – P. 107–109.

Razvodovsky Yu.Е. Alcohol and fatal injuries // Medical news. – 2011. – № 3. – P. 51–53.

Shashkova О.N., Izatulin V.G., Zobnin Yu.V. State of medullar hemopoiesis and some parenchymatous organs in conditions in poisoning with ethylene glycol // Siberian Medical Journal. – 2002. – Vol. 32, № 3. – P. 31–32.

Published

2020-06-29

How to Cite

Stadnik, S., & Porodko, B. (2020). Acute ethylene glycol poisoning in clinical practice. EMERGENCY MEDICINE, 16(4), 125–130. https://doi.org/10.22141/2224-0586.16.4.2020.207942

Issue

Section

Practicing Physician

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