Serotonin and epilepsy

Authors

  • Shorena Vashadze Shota Rustaveli State University, Batumi, Georgia
  • Mariam Kekenadze Tbilisi State Medical University, Tbilisi, Georgia
  • Sophio Brunjadze Shota Rustaveli State University, Batumi, Georgia

DOI:

https://doi.org/10.22141/2224-0586.18.2.2022.1475

Keywords:

serotonin, epilepsy

Abstract

Background. Studies of serotonin in epilepsy are numerous, but the importance of serotonin in this condition requires further study. The purpose of the study was to analyze the clinical features of patients with epilepsy and their serotonin levels in the blood serum during the interictal period. Materials and methods. The clinical research was conducted in Batumi Medical Center. Eighty individuals with epilepsy were examined: 35 (43.75 %) men and 45 (56.25 %) women; their mean age was 50 ± 7 years. All patients had a history of epileptic seizures for at least one year. Among them, there were 55 (68.75 %) people with symptomatic epilepsy who suffered organic brain injury. Symptomatic partial epilepsy was diagnosed in 3 (3.75 %) cases, while generalized epilepsy in 22 (27.5 %). The genesis of epilepsy was confirmed by neuroimaging technique (brain magnetic resonance imaging). Based on the analysis of clinical data, we isolated three groups of patients who differed in the severity and course of epilepsy and had no differences in the etiology of seizures, gender and age: group 1 — severely ill people with frequent epileptic seizures (5–10 times a year), with a chronic course of the disease; group 2 — individuals with stable disease course, patients with rare epileptic seizures (2–3 times a year); group 3 — those with a history of epilepsy of one year. The control group consisted of 20 apparently healthy patients. Results and сonclusions. In healthy people, serotonin levels decreased by 12.1 % (p < 0.04). In the group of patients with epilepsy duration of one year, serotonin levels increased. Patients with frequent seizures and severe epilepsy (group 1) had a decrease in serotonin (61.3 %). In individuals with a stable course of epilepsy (group 2), a moderate decrease in serotonin is observed, which is significantly lower than in the severe course of the disease (24.1 %, p < 0.05). Serotonin levels are higher in group 3 than in the first one. In group 1 patients, serotonin levels decreased to 2.541 ± 0.149 μm/l (p < 0.01). Activation of tryptophan metabolism is the cause of decreased serotonin level in patients with epilepsy. For all forms of epilepsy, there was a significant decrease in the interictal period compared to the control group. Studies have shown a relationship between the age of epilepsy manifestation and a decrease in the level of serotonin in the blood.

Downloads

Download data is not yet available.

References

Вашадзе Ш. Серотонинергическая система и когнитивная функция. Медицина невідкладних станів. 2019. 1(96). 112-117.

Shorena Vashadze. Depression of epileptic adults. International Academy of Science and Higher Education. London, United Kingdom. International Scientific Analytical Project. Available from: http://www.medicine.gisap.eu/author/138.

Dudas R., Malouf R., McCleery J. et al. Antidepressants for treating depression in dementia. Cochrane Database Syst. Rev. 2018 Apr 23. 4.

WHO. Информационный бюллетень ВОЗ. Деменция. Сайт ВОЗ (1 декабря 2017 года).

Rhett S. Thomson, Priscilla Auduong, Alexander T. Miller, Richard K. Gurgel. Hearing loss as a risk factor for dementia: a systematic review. Laryngoscope Investigative Otolaryngology. 2017. 2(2). 69-79. doi: 10.1002/lio2.65.

Thurman D.J., Begley C.E., Carpio A., Helmers S., Hesdorffer D.C., Mu J. et al. The primary prevention of epilepsy: a report of the Prevention Task Force of the International League Against Epilepsy. Epilepsia. 2018. 59(5). 905-14.

Taylor C.A., Bell J.M., Breiding M.J., Xu L. Traumatic brain injury-related emergency department visits, hospitalizations, and deaths — United States, 2007 and 2013. MMWR Surveill. Summ. 2017. 66(9). 1-16.

Majdan M., Plancikova D., Brazinova A., Rusnak M., Nieboer D., Feigin V. et al. Epidemiology of traumatic brain injuries in Europe: a cross-sectional analysis. Lancet Public Health. 2016. 1(2). e76-e83.

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Di­sease Study 2016. Lancet Neurology. 2019.

Gyorgy Bagdy, Valeria Kecskemeti, Pal Riba, Rita Jakus. Serotonin and epilepsy. Journal of Neurochemistry. 2007. 100. 857-873.

Downloads

Published

2022-05-19

How to Cite

Vashadze, S., Kekenadze, M., & Brunjadze, S. (2022). Serotonin and epilepsy. EMERGENCY MEDICINE, 18(2), 55–57. https://doi.org/10.22141/2224-0586.18.2.2022.1475

Issue

Section

Original Researches

Most read articles by the same author(s)