Poisoning of amino- and nitrocompounds of benzene |in occupational pathology


  • V.S. Tkachyshyn Bogomolets National Medical University, Kyiv, Ukraine




amino- and nitrocompounds of benzene, blood poisons, methemoglobin, sulfhemoglobin, acute and chronic intoxications, methylene blue


Amino- and nitrocompounds of benzene belong to the group of blood poisons. They lead to the formation of pathological hemoglobin compounds in the blood. Methemoglobin is formed during poisoning of amino- and nitrocompounds of benzene. In severe cases of poisoning there is an irreversible compound — sulfhemoglobin. Depending on the concentration and duration of contact, the amino- and nitrocompounds of benzene cause acute and chronic intoxication. Acute intoxication with these substances leads mainly to the formation of methemoglobin, secondary hemolytic anemia, damage to the central nervous system. When exposed to amino- and nitrocompounds of benzene, there are also signs of damage to the peripheral nervous system, liver, urinary tract, visual organ, skin and mucous membranes of the respiratory tract. Chronic intoxications with amino- and nitrocompounds of benzene lead to damage to the nervous system, parenchymal organs, mainly the liver, urinary tract, organ of vision. In chronic lesions, these compounds are carcinogenic. Bladder cancer is occurs. The antidote for poisoning by these substances is methylene blue, which is administered in 10–20 ml of 1% solution intravenously. Intravenous administration of 20–30 ml of 40% glucose solution is important. Oxygen therapy is also performed. In case of acute renal failure, hemodialysis or peritoneal dialysis is performed. Profilaxis is important to prevent poisoning.


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How to Cite

Tkachyshyn, V. (2022). Poisoning of amino- and nitrocompounds of benzene |in occupational pathology. EMERGENCY MEDICINE, 18(3), 31–35. https://doi.org/10.22141/2224-0586.18.3.2022.1487