Treatment of Patients with Central Fever Using Drugs for the Control of Mitochondrial Dysfunction
DOI:
https://doi.org/10.22141/2224-0586.7.78.2016.86095Keywords:
central fever, oxidative phosphorylation, mitochondrial dysfunction, non-steroidal anti-inflammatory drugs, severe traumatic brain injury, cerebral strokeAbstract
Cental fever — fever of infectious origin, complicating diseases of the central nervous system. Mechanisms of development are related to the dysfunction of the hypothalamus, which is considered as the center of thermoregulation. Central fever is associated with activation of catabolic reactions, adverse course of underlying pathological process and is hard to control using traditional therapeutic measures, including the use of non-steroidal anti-inflammatory drugs (NSAIDs). The research deals with the comparative study on the efficiency of central fever control in victims with severe traumatic brain injury and cerebral strokes using NSAIDs and a complex of vitamins and antioxidants, which help to improve the processes of association of mitochondrial oxidation and phosphorylation. Increase of this association provides the growth in the synthesis of adenosine triphosphate and inhibits the spread of free energy in the body as a heat. Each of the studied groups included 14 patients with severe injuries of the central nervous system and symptoms of central fever. There was found a significant advantage of treatment regimen that included the combined use of succinic acid, inosine, nicotinamide, riboflavin and thiamine over the commonly used treatment regimen based on the priority use of NSAIDs.Downloads
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