@article{Kolomachenko_Fesenko_2020, title={Dexmedetomidine as an adjuvant to bupivacaine in spinal anaesthesia for hip arthroplasty}, volume={16}, url={https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1281}, DOI={10.22141/2224-0586.16.5.2020.212230}, abstractNote={<em><strong>Background.</strong> </em>Spinal anaesthesia is a cost-effective technique for lower extremity surgery. One of its drawbacks is the short duration of postoperative analgesia. The purpose was to find out the effect of adding dexmedetomidine 5 or 10 μg to isobaric bupivacaine 12 mg on block characteristics in patients undergoing elective hip arthroplasty. <em><strong>Materials and methods.</strong> </em>Forty-five patients were randomly allocated to three groups, 15 people each: B group (bupivacaine only), BD5 group (bupivacaine and dexmedetomidine 5 μg), and BD10 group (bupivacaine and dexmedetomidine 10 μg). Motor block was assessed pre-operatively and post-operatively using modified Bromage scale. After surgery, time to the first need for systemic analgesia was registered.<em><strong> Results.</strong> </em>Before surgery, time to the onset of complete motor block (Me [25 %; 75 %]) in BD10 group (6.5 [5.0; 10] min) was insignificantly shorter than in BD5 group (10.0 [7.0; 15.0] min; p = 0.35) and B group (13.5 [10.0; 15.0] min; p = 0.08). After surgery, time to the onset of partial disappearance of motor block in BD10 group (540 [360; 660] min) was significantly (p < 0.001) longer than in BD5 (330 [300; 420] min) and B (200 [190; 240] min) groups; the difference between BD10 and BD5 groups was significant (p = 0.015), too. Time to the complete disappearance of motor block in BD10 group (630 [420; 720] min) was significantly (p < 0.001) longer than in BD5 (380 [340; 460] min) and B (255 [210; 280] min) groups; the difference between BD10 and BD5 groups was also significant (p = 0.008). Postoperatively, BD10 group showed a longer time to first need for systemic analgesia (720 [600; 860] min) than BD5 group (450 [400; 540] min; p = 0.0014) and B group (285 [230; 300] min; p < 0.001); BD5 group showed a longer time to first need for systemic analgesia than B group (p < 0.001). <em><strong>Conclusions.</strong> </em>Addition of dexmedetomidine prolongs both motor block and analgesia from spinal anaesthesia.}, number={5}, journal={EMERGENCY MEDICINE}, author={Kolomachenko, V.I. and Fesenko, V.S.}, year={2020}, month={Sep.}, pages={95–99} }