@article{Cherniy_Cherniy_2021, title={Modern principles of diagnosis and treatment of severe traumatic brain injury}, volume={17}, url={https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1413}, DOI={10.22141/2224-0586.17.5.2021.240700}, abstractNote={<p>Traumatic brain injury (TBI) is a heterogeneous syndrome that includes various types of trauma. About 10–15 % of patients have severe TBI, accompanied by high rates of disability and mortality. Currently, the methods of intensive care from the standpoint of evidence-based medicine are widely used for their treatment. Along with intensive care, the comprehensive cytoprotective program using Neurocitin®, which contains citicoline and electrolytes, is of great importance. Neurocitin® has a combined effect aimed at correcting metabolic and volemic disorders, namely, maintaining adequate cerebral perfusion, timely elimination of water-electrolyte disorders, energy supply of brain tissues and protection of the neurovascular unit from damage. Lactate in the composition of Neurocitin® provides a detoxification effect, preserves and increases the energy supply of neurons, improves metabolism, cerebral blood flow and neuronal activity. For the treatment of TBI, the neurometabolic drug of ethylmethylhydroxypyridine succinate (Lodixem®) is also used. Lodixem® normalizes cerebral blood flow, provides an earlier resolution of post-traumatic encephalopathy and restoration of consciousness, leads to a decrease in the severity of endogenous intoxication syndrome, the elimination of pathological vicious circles that arise against the background of hypoxia, ischemia and energy deficiency in various organs and tissues.</p>}, number={5}, journal={EMERGENCY MEDICINE}, author={Cherniy, V.I. and Cherniy, T.V.}, year={2021}, month={Sep.}, pages={6–12} }